| Disney California Adventure | theme park | — | February 8, 2001 |
| Disney Cruise Line | business, cruise line | Celebration | 1995 |
| Disney D23 | fan club, website, business | Burbank | 2009 |
| Disney Interactive Studios | video game developer | Glendale | December 5, 1994 |
| Disney Music Group | record label, record company, business | Burbank | 1998 |
| Disney Streaming | business | New York City | August 13, 2015 |
| Disney Television Studios | television production company, division | — | May 15, 2019 |
| Disney's Hollywood Studios | theme park | — | May 1, 1989 |
| Disneyland Hotel | hotel | — | 1955 |
| Docusign | business, public company | San Francisco | 2003 |
| Dodd, Mead & Co. | publishing house | New York City | 1839 |
| Dodge | car brand, business, enterprise, automobile manufacturer | Dodge Building | December 14, 1900 |
| Dodge & Cox | business, enterprise | San Francisco | 1930 |
| Dollar Tree | business, retail chain, public company | Chesapeake | 1986 |
| Dominican University | private not-for-profit educational institution, university, Catholic university | — | 1901 |
| Dover Corporation | business, public company | Downers Grove | 1955 |
| Dow Chemical Company | organization, business, enterprise, public company | Midland | 1897 |
| Dow Inc. | enterprise, public company | Midland | January 1, 2019 |
| Dow Jones & Company | business, enterprise | New York City | 1882 |
| Dr Pepper Snapple Group | business, public company | Plano | May 7, 2008 |
| Dr. Scholl's | brand, business | Chicago, London | 1906 |
| Drag City | independent record label | Chicago | 1990 |
| Dremel | trademark, business | Racine | 1932 |
| Drum Workshop | business, musical instrument manufacturing company, enterprise | Oxnard | 1972 |
| Duke University Press | open-access publisher, university press | Durham | 1921 |
| Dumbarton Oaks | research library, mansion, research institute, museum, academic publisher | — | 1940 |
| Dun & Bradstreet | business, subsidiary company, enterprise | — | 1841 |
| Dunkin' | fast food restaurant chain, business | Canton, Quincy | 1950 |
| Dunkin' Brands | business, enterprise, public company | Canton | 1950 |
| Dunlop Manufacturing | business, enterprise | Benicia | 1965 |
| Durant Motors | automobile manufacturer | Lansing | 1921 |
| Dyn | business | Manchester | 1998 |
| Dynatrace | software company, public company | Boston | February 2, 2005 |
| E-ZPass | business | Wilmington | 1987 |
| EA Mobile | video game developer | Los Angeles | 2004 |
| EA Sports | business | Burnaby | 1991 |
| Eagle Crest Resort | unincorporated community, hotel, census-designated place in the United States | — | 1985 |
| EarthLink | business, enterprise, public company | Atlanta, Pasadena, Atwater Village | 1994 |
| Eastern Air Lines | airline | Miami | 1926 |
| Eastern Illinois University | public educational institution of the United States, school of pedagogy, public university | — | 1895 |
| Eastman School of Music | conservatory | — | 1921 |
| Eataly | business, retail chain, enterprise | Monticello d'Alba | 2010 |
| EBSCO Information Services | business | Birmingham | 1943 |
| Eckert–Mauchly Computer Corporation | business | Philadelphia | 1948 |
| Eckō Unltd. | business, subsidiary company, brick and mortar | East Brunswick | 1993 |
| Eclipse Comics | comics publishing company, book publisher, business | Forestville, Staten Island | 1977 |
| Ecolab | business, public company | Saint Paul | 1923 |
| Econometric Society | open-access publisher, scientific society, learned society | — | December 29, 1930 |