| Currier and Ives | male duo, business | New York City | 1835 |
| Curtiss-Wright | holding company, business, public company, aerospace manufacturer | Charlotte | 1929 |
| Cushman & Wakefield | business, enterprise, public company | New York City | 1917 |
| CVS Health | organization, business, enterprise, public company | Rhode Island, Woonsocket | 1963 |
| CVS Pharmacy | business, pharmacy chain | Woonsocket | 1963 |
| Cypress Semiconductor | business | San Jose | 1982 |
| Da Capo Press | publishing house | Boston | 1964 |
| Dallas Semiconductor | business | Dallas | February 1, 1984 |
| Dallas Theological Seminary | private not-for-profit educational institution, seminary | — | 1924 |
| DallasNews Corporation | newspaper publisher, business, enterprise, company, public company | Dallas | 2008 |
| Dark Castle Entertainment | film production company | Los Angeles | 1999 |
| Dark Horse Entertainment | film production company | — | 1992 |
| Datadog | business, public company | New York City | 2010 |
| Datapoint | business | — | 1968 |
| DataStax | business | Santa Clara | April 2010 |
| Daybreak Game Company | video game developer | San Diego | 1995 |
| Dayton Art Institute | nonprofit organization, arts educational institution, art museum | Dayton | 1930 |
| DC Comics | comics publishing company, book publisher | Manhattan, Burbank | 1977 |
| DC Studios | film production company | Burbank | November 1, 2022 |
| DDB Worldwide | business | Chicago, San Francisco, London | 1949 |
| Dean Guitars | business, musical instrument manufacturing company | — | 1976 |
| Deep Space Industries | business, enterprise | Mountain View | January 22, 2013 |
| Deere & Company | business, enterprise, public company | Moline | 1868 |
| Defense Commissary Agency | supermarket chain, government agency | Fort Lee | October 1, 1991 |
| Delaware State University | historically black college or university, public educational institution of the United States, university, land-grant university | — | 1891 |
| Dell | business, enterprise, public company | Round Rock | September 7, 2016 |
| Dell Publishing | comics publishing company, publishing house | New York City | 1921 |
| Dell Technologies | business, enterprise, public company | Round Rock | September 7, 2016 |
| Delmark Records | record label, business, company | — | 1953 |
| Delmonico's | restaurant | — | December 13, 1827 |
| Delta State University | public educational institution of the United States, university | Cleveland | 1924 |
| DePauw University | liberal arts college, private not-for-profit educational institution | Greencastle | 1837 |
| Destination Films | film production company, film distributor | Culver City | 1999 |
| DeVry University | private university | — | 1931 |
| Diamond Multimedia | business | Los Angeles | 1982 |
| Diamond-Star Motors | business, automobile manufacturer | — | October 1985 |
| Dickies | business, enterprise, brick and mortar | Fort Worth | 1918 |
| Diebold Nixdorf | business, enterprise, public company | North Canton | 1859 |
| Digital Anvil | video game developer | Austin | 1996 |
| Digital Domain | public company | Playa Vista, Venice | 1993 |
| Digital Photography Review | website, business | — | 1998 |
| Digital Playground | pornographic film distributor, pornography company, pornographic film studio | Chatsworth, Van Nuys | 1993 |
| Digital Realty Trust | business, real estate investment trust, public company | Austin | 2004 |
| Dillard's | department store chain, public company | Little Rock | 1938 |
| Dimension Films | film production company | New York City | 1992 |
| Dimensional Fund Advisors | asset management company, business, enterprise | Austin | 1981 |
| Din Tai Fung | restaurant chain | Taipei | May 7, 1991 |
| Diners Club International | business, enterprise | Riverwoods | 1950 |