| Valero Energy | business, gas station chain, enterprise, public company | — | 1980 |
| Valiant Comics | comics publishing company, business | New York City | 1989 |
| Valparaiso University | private not-for-profit educational institution, open-access publisher, private university | Valparaiso | 1859 |
| Valve Corporation | computer manufacturer, software company, video game publisher, video game developer | Bellevue | 1996 |
| Vanguard Animation | production company, business | West Hollywood | 2002 |
| Varian Medical Systems | business, public company | Palo Alto | 1948 |
| VCA Pictures | pornographic film distributor, pornographic film studio | Culver City | — |
| Vector Motors | business, automobile manufacturer | — | 1978 |
| Vectrix | motorcycle manufacturer | Hong Kong | 2006 |
| Veeva Systems | business, public company | Pleasanton | 2007 |
| Venmo | online service, website, business | New York City | 2009 |
| Verbatim | business, enterprise | Charlotte | April 28, 1969 |
| Vercel Inc. | corporation, technology company, company | San Francisco | November 4, 2015 |
| VeriFone | business, public company | San Jose, Coral Springs | 1981 |
| Verso Books | publishing house | New York City, London | 1970 |
| Vertigo | book publisher, publishing house, imprint | Burbank, New York City | 1993 |
| VF Corporation | business, enterprise, public company | Denver, Greensboro | 1899 |
| Viacom | business, enterprise, public company | One Astor Plaza | December 31, 2005 |
| Viacom | production company, business | One Astor Plaza | May 3, 1971 |
| Viagogo | business, ticket sales service, ticket reseller | London | 2006 |
| Viatris | multinational corporation, pharmaceutical company, public company | Pittsburgh | November 2020 |
| Vici Properties | casino, real estate company, public company | New York City | October 6, 2017 |
| Victor Talking Machine Company | record company, business | Camden | 1901 |
| Victoria’s Secret | fashion label, business, brick and mortar, public company | Reynoldsburg | June 12, 1977 |
| Viki | online film database, website, business, online video platform, video streaming service, Internet audio-visual programming service provider | California | 2007 |
| Viking Press | book publisher, publishing house, imprint | New York City | 1925 |
| Vincent Bach Corporation | company-manufacturer of music accessories, business, musical instrument manufacturing company | Mount Vernon | 1918 |
| Virgin America | airline | Burlingame | 2004 |
| Virgin Galactic | airline, public company, aerospace manufacturer | Las Cruces | 2004 |
| Virginia Tech | public educational institution of the United States, United States senior military college, university, land-grant university | — | 1872 |
| Vishay Intertechnology | business, enterprise, public company | Malvern | 1962 |
| Vision Airlines | airline | Las Vegas | 1994 |
| Vivid Entertainment | pornographic film distributor, pornographic film studio | Los Angeles | 1984 |
| Viz Media, LLC | publishing house, business, company | San Francisco | 1984 |
| VLF Automotive | automobile manufacturer | Rochester | 2015 |
| Voat | dot-com company, social networking service, aggregator, social news website | — | 2014 |
| Von Dutch | business, enterprise | Los Angeles | 1999 |
| Vought | aerospace manufacturer | Dallas | 1917 |
| Vultee Aircraft | aerospace manufacturer | Downey | 1939 |
| Vyond | software company, privately held company, business | San Mateo | November 1, 2007 |