| F5, Inc. | software company, public company | Seattle | 1996 |
| Fairchild | aerospace manufacturer | — | 1925 |
| Fairfield University | private not-for-profit educational institution, Christian school, private university | — | 1942 |
| Fakku | pornography website, video game publisher, manga publisher | Portland | 2006 |
| Falcon Entertainment | pornographic film distributor, pornography website, pornographic film studio | San Francisco | 1971 |
| Fannie Mae | bank, business, state-owned enterprise of the United States | Northwest | 1938 |
| Fantagraphics Books | comics publishing company, book publisher | Seattle | 1976 |
| Faraday Future | automobile manufacturer | Gardena | 2014 |
| Fastenal | business, enterprise, public company | Winona | 1967 |
| Faulkner University | church college, private not-for-profit educational institution, university | — | 1942 |
| Fawcett Comics | publishing house | New York City | 1939 |
| FaZe Clan | esports team, public company, clan | — | — |
| Federal Home Loan Banks | business, credit institution | Boston, Chicago, Pittsburgh, Dallas, Atlanta, Des Moines, Topeka, Cincinnati, New York City, San Francisco, Indianapolis | 1932 |
| Federal Reserve Bank of Cleveland | organization, Federal Reserve Bank | Federal Reserve Bank Building | May 18, 1914 |
| Federal Reserve Bank of Kansas City | organization, Federal Reserve Bank | 1 Memorial Drive, 925 Grand | — |
| Federal Reserve Bank of Minneapolis | publishing house, organization, Federal Reserve Bank | Minneapolis | 1914 |
| Federal Reserve Bank of Philadelphia | organization, Federal Reserve Bank | — | 1914 |
| FedEx Office | business, retail chain | Dallas | 1970 |
| FEI Company | business, enterprise, public company | Hillsboro | 1971 |
| Fenway Sports Group | business, enterprise | Boston | 2001 |
| Ferris State University | public educational institution of the United States, university | Big Rapids | 1884 |
| Fidelity Investments | business, enterprise | Boston | 1946 |
| Fidelity National Information Services | business, public company | — | February 1, 2006 |
| Filmation | animation studio, film studio | Reseda | 1962 |
| Fiorello H. LaGuardia High School | high school | — | 1961 |
| Firaxis Games | video game developer | Sparks | 1996 |
| Firebase | service on Internet, software framework, business | San Francisco | 2010 |
| Firefly Aerospace | launch service provider, business | Cedar Park | 2014 |
| Firehouse Subs | business | — | 1994 |
| First Data | business | Atlanta | 1969 |
| First Look Media | news agency | New York City | 2013 |
| First National Pictures | film production company | United States | 1917 |
| FirstEnergy | business, public company | Akron | 1997 |
| Fiserv | business, enterprise, public company | Brookfield | 1984 |
| Fitbit | privately held company, organization, business, enterprise | San Francisco | 2007 |
| Fleischer Studios | film studio | New York City, Florida | 1921 |
| Florida A&M University | historically black college or university, public educational institution of the United States, school, university, land-grant university | — | 1887 |
| Florida Atlantic University | public educational institution of the United States, university | Boca Raton | 1961 |
| Florida Institute of Technology | university of technology, private not-for-profit educational institution | Melbourne | September 22, 1958 |
| Florsheim Shoes | business | Glendale | 1892 |
| FMC Corporation | business, enterprise, public company | BNY Mellon Center | 1883 |
| Folger Shakespeare Library | Shakespeariana, library, art collection, library building | — | 1932 |
| Fontainebleau Las Vegas | skyscraper, casino, hotel, resort | — | 2023 |
| Fontainebleau Miami Beach | convention center, hotel, landmark, resort | Miami Beach | 1954 |
| Foot Locker | business, enterprise, shoe store chain, public company | New York City | 1974 |
| Ford Aerospace | business | Milpitas | 1956 |
| Ford Foundation | production company, nonprofit organization, collection | Ford Foundation Center for Social Justice | 1936 |
| Fordham University | nonprofit organization, private not-for-profit educational institution, private university | New York City | 1841 |
| Fort Bliss | military base, Training Center of the German Airforce, census-designated place in the United States | — | 1849 |
| Fortress Investment Group | public company | 1345 Avenue of the Americas | 1998 |
| Fox Corporation | media company, holding company, public company | New York City | 2019 |
| Fox Crime | television production company, television channel | — | 2005 |
| Fox Entertainment Group | television production company, public company | Fox Plaza | 1985 |
| Fox Film Corporation | production company, film production company, film studio | Hollywood | 1915 |
| Fox Kids | television production company, television channel, specialty channel | United States | September 8, 1990 |
| Fox Networks Group | television production company, business | Los Angeles | 1993 |
| Framingham State University | public educational institution of the United States, university | — | 1839 |
| Frederator Studios | business | New York City | 1997 |
| Freeport-McMoRan | business, enterprise, public company | Phoenix | 1912 |
| Frito-Lay | business | Plano | 1961 |
| Frog City Software | video game developer | San Francisco | 1995 |
| Frogdesign | organization, business | San Francisco | 1969 |
| Fuller Theological Seminary | private not-for-profit educational institution, seminary, university | Pasadena | 1947 |
| Funny or Die | business | San Mateo | April 12, 2007 |
| Furman University | liberal arts college, private not-for-profit educational institution | Greenville | 1826 |
| Fusion-io | business, enterprise | Cottonwood Heights | 2006 |
| Future Shop | business | Burnaby | 1982 |
| Fuzzy Door Productions | film production company, record label | Universal City, Los Angeles | 1998 |
| FX | television production company, cable channel | Texas, New York City, Pico Boulevard | June 1, 1994 |