| Wellington Management Company | business, enterprise | Boston | 1928 |
| West Chester University of Pennsylvania | public educational institution of the United States, university | — | 1871 |
| West Virginia University | public educational institution of the United States, open-access publisher, land-grant university, public research university | Morgantown | 1867 |
| Western Carolina University | public educational institution of the United States, university | — | 1889 |
| Western Connecticut State University | public educational institution of the United States, university | Danbury | 1893 |
| Western Electric | organization, business, enterprise | New York City | 1869 |
| Western Global Airlines | airline | Estero | March 6, 2013 |
| Western Pacific Railroad | business, transport company | San Francisco | 1916 |
| Westinghouse Air Brake Company | manufacturing company, business | Pittsburgh | 1869 |
| Westwood Studios | video game developer, business | Las Vegas | 1992 |
| Wexner Center for the Arts | art gallery, art museum, movie theater | — | 1989 |
| White Castle | fast food restaurant chain | Columbus | 1921 |
| White Motor Company | business, automobile manufacturer | Cleveland | 1902 |
| WHOOP | business | Boston | — |
| Wichita State University | public educational institution of the United States, university | — | 1886 |
| Wiley | book publisher, publishing house, educational publishing company, open-access publisher, public company, academic publisher | Hoboken | 1807 |
| Wilhelmina Models | modeling agency, public company | New York City | 1967 |
| William Cramp & Sons | shipbuilding company | Philadelphia | 1830 |
| Williams Companies | energy company, public company | Tulsa | 1908 |
| Williams International | business, enterprise | Commerce Township | 1954 |
| Willys | business, automobile manufacturer | Toledo | 1908 |
| Winchester Repeating Arms Company | business, enterprise | New Haven | 1866 |
| Windows on the World | restaurant | — | 1976 |
| Winnebago Industries | business, enterprise, public company | Eden Prairie | February 12, 1958 |
| Winter Garden Theatre | Broadway theatre, theatre building, movie theater | — | March 10, 1911 |
| Wish.com | online marketplace, business, mobile app, enterprise | San Francisco | 2010 |
| WiTricity | business | Watertown | 2007 |
| Wizards of the Coast | tabletop role-playing game publisher, video game publisher, board game publishing company, business | Renton | 1990 |
| WME Group | record label, business, talent agency, public company | Beverly Hills | 1898 |
| Wolfram Research | business | Champaign | 1987 |
| Wolfspeed | business, enterprise, public company | Durham | 1987 |
| Woods Hole Oceanographic Institution | nonprofit organization, educational institution, research institute | Woods Hole | 1930 |
| Woot | business | Carrollton | 2004 |
| Worcester Polytechnic Institute | private not-for-profit educational institution, university | — | 1865 |
| World Class Championship Wrestling | business | Dallas | 1966 |
| World Digital Library | digital library, website | Washington, D.C. | — |
| World of Wonder | film production company | Hollywood | 1991 |
| Wright State University | public educational institution of the United States, public research university | — | 1964 |
| Wrigley Company | business | Chicago | April 1, 1891 |
| Wrike Inc. | business | Mountain View | 2006 |
| Wyndham Hotels & Resorts | hotel chain, business, public company | Parsippany-Troy Hills | June 1, 2018 |
| X Corp. | privately held company, technology company, business | Bastrop | March 9, 2023 |
| XBIZ | business, online magazine | Los Angeles | 1998 |
| XCOR Aerospace | business | Mojave Air and Space Port at Rutan Field | September 1999 |
| Xerox | business, enterprise | Norwalk | April 18, 1906 |
| Ximian | business, enterprise | Boston | October 19, 1999 |
| XPO, Inc. | logistics company, business, enterprise, public company | Greenwich | 1987 |
| XYZ Films | film studio | Los Angeles | 2008 |