| Rivian Automotive | business, enterprise, automobile manufacturer, public company | Detroit | June 2009 |
| RJR Nabisco | business | Cobb County, Winston-Salem, New York City | April 25, 1986 |
| RKO Pictures | film production company, film distributor, business | Manhattan | October 23, 1928 |
| Robinhood | brokerage firm, business, public company | Palo Alto | 2013 |
| Robinson Helicopter Company | business, enterprise | Zamperini Field | 1973 |
| Rochester Institute of Technology | university of technology, research university, engineering school, space grant institution, private not-for-profit educational institution, open-access publisher, private university | — | June 12, 1829 |
| Rockstar New England | video game developer | Andover | 1999 |
| Rockwell Collins | defense contractor, business, public company, aerospace manufacturer | Cedar Rapids | 1933 |
| Rogue | film production company | Universal City | 1997 |
| Room to Read | nonprofit organization, business | San Francisco | 2000 |
| Rooster Teeth | YouTube channel, film production company | Austin, Los Angeles, Flower Mound | April 1, 2003 |
| Rough Draft Studios | business, enterprise | Glendale | 1990 |
| Rowman & Littlefield | book publisher, publishing house | Lanham | 1949 |
| Roxy Theatre | nightclub, music venue | — | September 23, 1973 |
| Royal Caribbean Group | business, enterprise, public company | Miami | 1997 |
| Royal Caribbean International | cruise line | Miami | 1968 |
| RSA | business, enterprise | Bedford | 1986 |
| RTX | defense contractor, business, public company | Arlington County | April 3, 2020 |
| Running with Scissors | video game developer | Tucson | 1996 |
| Rutgers University Press | university press | New Brunswick | 1936 |
| Rutherford B. Hayes Presidential Center | library | — | 1912 |
| Ryan Aeronautical | business | San Diego | 1934 |
| Ryder | business, retail chain, public company | Coral Gables | 1933 |
| S2 Games | video game developer | Kalamazoo | 2003 |
| Saber Interactive | video game developer | Fort Lauderdale, Minsk, Sundsvall, Porto, Millburn, Community of Madrid, Saint Petersburg, Florida | 2001 |
| SAE International | engineering society, regulatory college, standards organization, business, company, academic publisher | Warrendale | 1905 |
| Safeway | supermarket chain, business, enterprise, public company | Pleasanton | 1915 |
| Sahara Las Vegas | skyscraper, hotel, casino hotel, music venue | — | 1952 |
| Saint Anselm College | private not-for-profit educational institution, liberal arts college in the United States | Manchester | 1889 |
| Sam's Club | supermarket chain | Bentonville | 1983 |
| San Diego FC | association football club, business | San Diego | May 18, 2023 |
| San Francisco Museum of Modern Art | nonprofit organization, art museum, publishing house, museum, museum of modern art | San Francisco | 1935 |
| San Francisco Opera | nonprofit organization, opera company | San Francisco | 1923 |
| San Francisco State University | public educational institution of the United States, university | — | 1899 |
| Sandisk | technology company, brand, business, enterprise | Milpitas | June 1, 1988 |
| Santa Monica Studio | video game developer | Playa Vista | 1999 |
| Schomburg Center for Research in Black Culture | library branch, creative residency, research library, public library, library building | — | 1925 |
| School of Visual Arts | private for-profit educational institution, art academy, university | New York City | 1947 |
| Schwinn Bicycle Company | business | Chicago | 1895 |
| Scribd | online service, organization, business | San Francisco | March 2006 |
| Sealy Corporation | business, enterprise, public company | Trinity | 1881 |
| Sean Cody | pornography website, pornographic film studio | United States | 2001 |
| Sears | business, public company | Hoffman Estates | 1892 |
| Sears Holdings Corporation | business, enterprise, public company | Hoffman Estates | 2005 |
| Seattle Computer Products | business | Seattle | 1979 |
| Seattle's Best Coffee | business | Seattle | 1991 |
| SeaWorld | business, chain | Orlando | March 21, 1964 |
| Selig Polyscope Company | film production company | Los Angeles | 1896 |