| Sony Corporation of America | 550 Madison Avenue, New York City | 1960 |
| Sony Entertainment | New York City | 2012 |
| Sony Imagesoft | Los Angeles | 1989 |
| Sony Music | New York City | January 1, 2009 |
| Sony Pictures Motion Picture Group | Culver City | 1998 |
| Soylent | Los Angeles | 2013 |
| SpaceX | Starbase | March 14, 2002 |
| Spansion | Sunnyvale | 2003 |
| Specialized Bicycle Components | Morgan Hill | 1974 |
| Spector | Saugerties | 1976 |
| Spectrum Brands | Middleton | 1906 |
| Sports Reference | Philadelphia | December 3, 2007 |
| Springfield Armory | Geneseo | 1974 |
| Sprint Corporation | Overland Park | 1899 |
| Standard Oil | Ohio, Cleveland, New York City | 1890 |
| Stanley Black & Decker | New Britain | 1843 |
| Staples Inc. | Framingham | 1986 |
| Starwood | White Plains | 1930 |
| State Farm Insurance | Bloomington | 1922 |
| Steak 'n Shake | Indianapolis | 1934 |
| Steinway Musical Instruments | Waltham | 1995 |
| Stratfor | Austin | 1996 |
| Stratolaunch Systems | Montgomery, Seattle | 2011 |
| Stripe | San Francisco, South San Francisco | 2010 |
| Studebaker | South Bend | 1852 |
| Stüssy, Inc. | Irvine | 1980 |
| Sumisho Air Lease | Los Angeles | 2010 |
| Sunkist Growers | Los Angeles | August 29, 1893 |
| SureFire | Fountain Valley | 1979 |
| SurveyMonkey | San Mateo | 1999 |
| Swift Engineering | San Clemente | 1983 |
| Synopsys | Mountain View | 1986 |
| Sysco | Houston | 1969 |
| System76 | Denver | November 7, 2005 |
| TaylorMade Golf Company | Carlsbad | 1979 |
| Tazo | Portland | 1994 |
| Teledyne FLIR | Wilsonville | 1978 |
| Teledyne Technologies | Thousand Oaks | 1960 |
| Telltale Games | San Rafael | July 2004 |
| Tennessee Valley Authority | Knoxville | 1933 |
| Tesla Energy | Fremont | — |
| Texaco | San Ramon | 1901 |
| Texas Instruments | Dallas | December 6, 1930 |
| The Athletic | San Francisco | January 2016 |
| The Atlantic | Washington, D.C. | 1857 |
| The Babylon Bee | Jupiter | March 1, 2016 |
| The Boring Company | Hawthorne | December 17, 2016 |
| The Cigna Group | Bloomfield | 1982 |