| Ring of Honor | — | 2002 |
| Rivian Automotive | Detroit | June 2009 |
| RJR Nabisco | Cobb County, Winston-Salem, New York City | April 25, 1986 |
| RKO Pictures | Manhattan | October 23, 1928 |
| Robinhood | Palo Alto | 2013 |
| Robinson Helicopter Company | Zamperini Field | 1973 |
| Rockwell Collins | Cedar Rapids | 1933 |
| Room to Read | San Francisco | 2000 |
| Rough Draft Studios | Glendale | 1990 |
| Royal Caribbean Group | Miami | 1997 |
| RSA | Bedford | 1986 |
| RTX | Arlington County | April 3, 2020 |
| Ryan Aeronautical | San Diego | 1934 |
| Ryder | Coral Gables | 1933 |
| SAE International | Warrendale | 1905 |
| Safeway | Pleasanton | 1915 |
| San Diego FC | San Diego | May 18, 2023 |
| Sandisk | Milpitas | June 1, 1988 |
| Schwinn Bicycle Company | Chicago | 1895 |
| Scribd | San Francisco | March 2006 |
| Sealy Corporation | Trinity | 1881 |
| Sears | Hoffman Estates | 1892 |
| Sears Holdings Corporation | Hoffman Estates | 2005 |
| Seattle Computer Products | Seattle | 1979 |
| Seattle's Best Coffee | Seattle | 1991 |
| SeaWorld | Orlando | March 21, 1964 |
| Semrush | Boston | August 3, 2008 |
| Shen Yun | Deerpark | 2006 |
| Sheraton Hotels and Resorts | White Plains | 1937 |
| Sherwin-Williams | Cleveland | 1866 |
| Shiny Entertainment | Laguna Beach, Newport Beach | 1993 |
| Showtime | New York City | 1983 |
| Silicon Laboratories | Austin | 1996 |
| Silver Pictures | Los Angeles | 1980 |
| Silvergate Capital | La Jolla | 1988 |
| Similarweb | Givatayim | 2007 |
| Sinclair Broadcast Group | Hunt Valley, Cockeysville, Union Valley | 1971 |
| Sirius Satellite Radio | New York City | May 17, 1990 |
| Six Flags | Arlington | 1961 |
| Six Flags | Charlotte | July 1, 2024 |
| Skechers | Manhattan Beach | 1992 |
| Sketchfab | New York City | 2012 |
| Skydance Media | Hollywood | 2006 |
| Slack Technologies | San Francisco | 2009 |
| SLB | Houston | 1926 |
| Snap-on | Kenosha | 1920 |
| Snowflake Inc. | San Mateo | 2012 |
| SolarCity | San Mateo, California | 2006 |