| United Space Alliance | Houston | August 1995 |
| United States Playing Card Company | Erlanger | 1867 |
| United States Rubber Company | Naugatuck | 1892 |
| United States Wrestling Association | Memphis | 1989 |
| Upjohn | Michigan, Kalamazoo | 1886 |
| Upwork | Palo Alto | 2015 |
| URS Corporation | Transamerica Pyramid, San Francisco | 1951 |
| US Foods | Rosemont | August 1, 1989 |
| USAA | — | 1922 |
| UUNET | Ashburn | 1987 |
| Valero Energy | — | 1980 |
| Valiant Comics | New York City | 1989 |
| Vanguard Animation | West Hollywood | 2002 |
| Varian Medical Systems | Palo Alto | 1948 |
| Vector Motors | — | 1978 |
| Veeva Systems | Pleasanton | 2007 |
| Venmo | New York City | 2009 |
| Verbatim | Charlotte | April 28, 1969 |
| VeriFone | San Jose, Coral Springs | 1981 |
| VF Corporation | Denver, Greensboro | 1899 |
| Viacom | One Astor Plaza | December 31, 2005 |
| Viacom | One Astor Plaza | May 3, 1971 |
| Viagogo | London | 2006 |
| Victor Talking Machine Company | Camden | 1901 |
| Victoria’s Secret | Reynoldsburg | June 12, 1977 |
| Viki | California | 2007 |
| Vincent Bach Corporation | Mount Vernon | 1918 |
| Vishay Intertechnology | Malvern | 1962 |
| Viz Media, LLC | San Francisco | 1984 |
| Von Dutch | Los Angeles | 1999 |
| Vyond | San Mateo | November 1, 2007 |
| Wabtec | Wilmerding | 1999 |
| Waco | Troy | 1919 |
| Waldorf Astoria Hotels and Resorts | — | 2006 |
| Walmart | Bentonville | October 31, 1969 |
| Walt Disney Imagineering | Glendale | 1952 |
| Walt Disney Motion Pictures Group | Burbank | 1998 |
| Warner Bros. Discovery | New York City | April 8, 2022 |
| Warner Bros. Records Inc. | New York City | March 19, 1958 |
| WarnerMedia | Delaware, New York City | 2016 |
| Warrior Sports | Warren | 1992 |
| WatchGuard | Seattle | February 1996 |
| Waterman | Paris | 1883 |
| Waters Corporation | Milford | 1958 |
| Weatherby | Sheridan, Paso Robles | 1945 |
| Weber-Stephen Products | Palatine | May 8, 1893 |
| Webex by Cisco | Milpitas | 1995 |
| Welch's | Concord | 1869 |