| Abbott-Detroit | automobile manufacturer | Detroit | 1909 |
| American Axle | business, enterprise, public company | Detroit | 1994 |
| Auburn Automobile | business | Auburn | 1900 |
| BorgWarner | business, enterprise, public company | Auburn Hills | 1880 |
| Cadillac | automobile manufacturer | Detroit | 1902 |
| Canoo | business, automobile manufacturer, public company | Torrance | 2017 |
| Carfax | business, corporation | Centreville | 1984 |
| Chevrolet | car brand, automobile manufacturer | Detroit | November 3, 1911 |
| Cord Automobile | business | United States | 1929 |
| Crosley | business, automobile manufacturer | Cincinnati | 1937 |
| Diamond-Star Motors | business, automobile manufacturer | — | October 1985 |
| Dodge | car brand, business, enterprise, automobile manufacturer | Dodge Building | December 14, 1900 |
| Durant Motors | automobile manufacturer | Lansing | 1921 |
| Faraday Future | automobile manufacturer | Gardena | 2014 |
| Graham-Paige | business, automobile manufacturer | Evansville | 1927 |
| Harley-Davidson | motorcycle manufacturer | Milwaukee | 1903 |
| Hudson Motor Car Company | business, automobile manufacturer | Detroit | 1909 |
| Hupmobile | business, automobile manufacturer | Detroit | 1909 |
| Indian Motorcycle | motorcycle manufacturer, subsidiary company, enterprise | Kings Mountain, Medina | 1901 |
| Intermeccanica | automobile manufacturer | Vancouver | 1959 |
| Jeep | car brand, business, enterprise, automobile manufacturer | Toledo | 1941 |
| Kaiser Jeep | business, automobile manufacturer | Toledo | 1953 |
| Lincoln Motor Company | car brand, automobile manufacturer, public company | Dearborn | 1917 |
| Mack Trucks | business, enterprise | Allentown, Greensboro | 1900 |
| Mosler Automotive | automobile manufacturer | Riviera Beach | 1985 |
| Oakland Motor Car Company | automobile manufacturer | Pontiac | 1907 |
| Oldsmobile | car brand, division, automobile manufacturer | Lansing | 1897 |
| Oshkosh Corporation | business, enterprise, public company | Oshkosh | 1917 |
| Pierce-Arrow | business, automobile manufacturer | Buffalo | 1870 |
| Polaris | motorcycle manufacturer, enterprise, automobile manufacturer, public company | Medina | 1954 |
| Pope Manufacturing Company | automobile manufacturer | Hartford | 1876 |
| Ram Trucks | car brand, division, automobile manufacturer | Auburn Hills | 2010 |
| REO Motor Car Company | business, automobile manufacturer | Lansing | 1905 |
| Rivian Automotive | business, enterprise, automobile manufacturer, public company | Detroit | June 2009 |
| SAE International | engineering society, regulatory college, standards organization, business, company, academic publisher | Warrendale | 1905 |
| Sterling Trucks | truck manufacturer, commercial vehicle manufacturer | Redford | 1997 |
| Studebaker | business, automobile manufacturer | South Bend | 1852 |
| TRW Automotive | business, enterprise, public company | — | — |
| U-Haul | car rental company, business, public company | Phoenix | 1945 |
| Vector Motors | business, automobile manufacturer | — | 1978 |
| White Motor Company | business, automobile manufacturer | Cleveland | 1902 |
| Willys | business, automobile manufacturer | Toledo | 1908 |
| Winnebago Industries | business, enterprise, public company | Eden Prairie | February 12, 1958 |