| Oshkosh Corporation | Oshkosh | 1917 |
| Otis Worldwide Corporation | Farmington | 1853 |
| Pacific Gas and Electric Company | Pacific Gas & Electric Building, San Francisco | 1905 |
| Panera Bread | Sunset Hills | 1987 |
| Parametric Technology Corporation | Boston | May 1985 |
| Philip Morris International | Stamford, Lausanne | 1987 |
| Planet Labs | San Francisco | December 28, 2010 |
| PNC Financial Services | One PNC Plaza | 1982 |
| Polaris | Medina | 1954 |
| Polycom | San Jose | 1990 |
| Principal Financial Group | Des Moines | 1879 |
| Publix | Lakeland | December 27, 1921 |
| Qualcomm | San Diego | July 1985 |
| Qualtrics | Provo | 2002 |
| Quiksilver | Huntington Beach | 1969 |
| Revlon | New York City | 1932 |
| Reynolds American | Winston-Salem | 2004 |
| Rivian Automotive | Detroit | June 2009 |
| Robinhood | Palo Alto | 2013 |
| Rockwell Collins | Cedar Rapids | 1933 |
| Royal Caribbean Group | Miami | 1997 |
| RTX | Arlington County | April 3, 2020 |
| Ryder | Coral Gables | 1933 |
| Safeway | Pleasanton | 1915 |
| Sealy Corporation | Trinity | 1881 |
| Sears | Hoffman Estates | 1892 |
| Sears Holdings Corporation | Hoffman Estates | 2005 |
| Semrush | Boston | August 3, 2008 |
| Sherwin-Williams | Cleveland | 1866 |
| Silicon Laboratories | Austin | 1996 |
| Silvergate Capital | La Jolla | 1988 |
| Similarweb | Givatayim | 2007 |
| Sinclair Broadcast Group | Hunt Valley, Cockeysville, Union Valley | 1971 |
| Six Flags | Arlington | 1961 |
| Six Flags | Charlotte | July 1, 2024 |
| Skechers | Manhattan Beach | 1992 |
| Slack Technologies | San Francisco | 2009 |
| SLB | Houston | 1926 |
| Snap-on | Kenosha | 1920 |
| Snowflake Inc. | San Mateo | 2012 |
| SolarCity | San Mateo, California | 2006 |
| SoundHound | Santa Clara | September 2005 |
| SpaceX | Starbase | March 14, 2002 |
| Spansion | Sunnyvale | 2003 |
| Spectrum Brands | Middleton | 1906 |
| Sprint Corporation | Overland Park | 1899 |
| Squarespace | New York City | 2003 |
| Stanley Black & Decker | New Britain | 1843 |