| Dun & Bradstreet | — | 1841 |
| Dunkin' Brands | Canton | 1950 |
| Dunlop Manufacturing | Benicia | 1965 |
| EarthLink | Atlanta, Pasadena, Atwater Village | 1994 |
| Eataly | Monticello d'Alba | 2010 |
| Elevance Health, Inc. | Indianapolis | 2004 |
| Energizer Holdings, Inc. | St. Louis | 2000 |
| Enron | Houston | 1985 |
| EPAM Systems | Newtown, Pennsylvania | 1993 |
| Epicor | Austin, Irvine | 1972 |
| Epyx | San Francisco | 1978 |
| Estée Lauder Companies | Neuilly-sur-Seine, New York City | 1946 |
| Exelon | Chicago | 2000 |
| Expedia Group | Seattle | October 22, 1996 |
| Expeditors International | Seattle | 1979 |
| ExxonMobil | Spring | August 5, 1882 |
| Fastenal | Winona | 1967 |
| FEI Company | Hillsboro | 1971 |
| Fenway Sports Group | Boston | 2001 |
| Fidelity Investments | Boston | 1946 |
| Fiserv | Brookfield | 1984 |
| Fitbit | San Francisco | 2007 |
| FMC Corporation | BNY Mellon Center | 1883 |
| Foot Locker | New York City | 1974 |
| Freeport-McMoRan | Phoenix | 1912 |
| Fusion-io | Cottonwood Heights | 2006 |
| GameStop | Grapevine | August 20, 1980 |
| General American Transportation Corporation | Chicago | 1933 |
| General Atomics Aeronautical Systems | Poway | 1993 |
| Genesys | Daly City | 1990 |
| Genzyme | Cambridge | 1981 |
| Georgia-Pacific | Atlanta, Georgia-Pacific Tower | 1927 |
| Giant Sparrow | Santa Monica | March 22, 2009 |
| GlobalFoundries | Malta | October 7, 2008 |
| Glu Mobile | San Francisco | 2005 |
| GNC | Pittsburgh | 1935 |
| GoTo | Boston | 2003 |
| Grubhub | Chicago | 2004 |
| GTE | Stamford | 1918 |
| Harman International Industries | Stamford | 1980 |
| Hasbro | Pawtucket | 1923 |
| HEAD | Kennelbach | 1950 |
| Hercules Computer Technology | California | 1982 |
| Hewlett Packard Enterprise | Spring | November 1, 2015 |
| Hill & Knowlton | New York City | 1927 |
| Holland America Line | Seattle | 1873 |
| Honeywell Aerospace | Phoenix | 1936 |
| Hormel | Austin | 1891 |