| Bicycle Playing Cards | Erlanger | — |
| Bigelow Aerospace | North Las Vegas | 1999 |
| Bio-Rad Laboratories | Hercules | 1952 |
| Biogen | Cambridge | 1978 |
| Bitly | New York City | 2008 |
| Black Diamond Equipment | Holladay | December 1, 1989 |
| BlackRock | New York City | 1988 |
| Blackstone Inc. | New York City | 1985 |
| Blinding Edge Pictures | Berwyn | 1999 |
| Blockbuster LLC | Dallas | 1985 |
| Bloomberg L.P. | New York City, 731 Lexington Avenue | October 1, 1981 |
| Blu Products | Doral, Paramount | 2009 |
| Bluehost | Provo | 2022 |
| BMC Software | Houston | 1980 |
| Bobcat Company | West Fargo | 1947 |
| Booking Holdings | Norwalk | July 1997 |
| Borders Group | Ann Arbor | 1971 |
| BorgWarner | Auburn Hills | 1880 |
| Bose Corporation | Framingham | 1964 |
| Boston Dynamics | Waltham | November 6, 1992 |
| Boston Scientific | Marlborough | June 29, 1979 |
| Box | Redwood City | May 2009 |
| Brightstar Corporation | Miami | 1997 |
| Broadcom | Palo Alto | 1961 |
| Broadwood and Sons | New York City, London | 1732 |
| Brooklyn–Manhattan Transit Corporation | Brooklyn | 1923 |
| Brooks Brothers | New York City | 1818 |
| Browning Arms Company | Morgan | 1927 |
| Bucyrus International | South Milwaukee | 1880 |
| Budget Rent a Car | Chicago, Parsippany-Troy Hills | 1958 |
| Build-A-Bear Workshop | St. Louis | 1997 |
| Bunge Limited | Hamilton, White Plains | 1818 |
| Burton Snowboards | Burlington | 1977 |
| C. F. Martin & Company | Nazareth | 1833 |
| C. H. Robinson Worldwide | Eden Prairie | 1905 |
| Caesars Entertainment Corporation | Las Vegas, Paradise | 1937 |
| Cannondale Bicycle Corporation | Bethel | 1971 |
| Canoo | Torrance | 2017 |
| Captain D's | Nashville | August 15, 1969 |
| Caravan Pictures | Santa Monica | 1992 |
| Cardinal Health | Dublin | 1971 |
| Carfax | Centreville | 1984 |
| Carlson Wagonlit Travel | Minneapolis | 1994 |
| Carnival Corporation | Doral, Southampton, Florida, London, Miami | 1972 |
| Caterpillar Inc. | Irving | 1925 |
| CBS Corporation | CBS Building | November 30, 1997 |
| Celestron | Torrance | 1960 |
| Celgene | Summit | 1986 |