| Pyra Labs | business | 1999 |
| Reddit | user-generated content platform, art-sharing website, news aggregation website, social networking service, aggregator, social news website, online community | June 23, 2005 |
| Replit | business, online integrated development environment | — |
| Room to Read | nonprofit organization, business | 2000 |
| San Francisco Museum of Modern Art | nonprofit organization, art museum, publishing house, museum, museum of modern art | 1935 |
| San Francisco Opera | nonprofit organization, opera company | 1923 |
| Scribd | online service, organization, business | March 2006 |
| Slack Technologies | business, public company | 2009 |
| Stripe | payment processor, business | 2010 |
| The Athletic | online newspaper, podcast network, business, sports journalism | January 2016 |
| Titan Media | pornography website, pornographic film studio | 1995 |
| Twitter, Inc. | privately held company, public company | April 19, 2007 |
| Union Iron Works | business | 1849 |
| URS Corporation | business, enterprise | 1951 |
| Vercel Inc. | corporation, technology company, company | November 4, 2015 |
| Viz Media, LLC | publishing house, business, company | 1984 |
| Western Pacific Railroad | business, transport company | 1916 |
| Wish.com | online marketplace, business, mobile app, enterprise | 2010 |
| Yerba Buena Center for the Arts | nonprofit organization, museum, movie theater, built structure | — |