| Alliant University | private for-profit educational institution, university | 2001 |
| Daybreak Game Company | video game developer | 1995 |
| Harcourt | publishing house | 1919 |
| High Moon Studios | video game developer | 2001 |
| Illumina | business, enterprise, company, public company | 1998 |
| Maxwell Technologies | business | 1965 |
| Naughty America | pornographic film distributor, pornographic film studio | 2001 |
| Nik Software | business | 1995 |
| One America News Network | news website, television channel, organization, subscription television, cable news in the United States | July 4, 2013 |
| Petco | pet store chain, business | 1965 |
| Psyonix | video game developer | 2000 |
| Qualcomm | business, public company | July 1985 |
| Ryan Aeronautical | business | 1934 |
| San Diego FC | association football club, business | May 18, 2023 |
| University of San Diego | private not-for-profit educational institution, private university | 1949 |